A research group in Singapore has developed a nano coating that can kill bacteria on surfaces and water
L-R: The researchers from IBN, Dr Guangshun Yi, Dr Yuan Yuan, Dr Xiukai Li and Dr Yugen Zhang, who developed the dragonfly-inspired nano coating that can kill bacteria spontaneously upon contact. Dr Yi is holding up a piece of zinc coated with zinc oxide nanopillars. Photo IBN
A new nano coating with antimicrobial properties has been developed by a research group in Singapore. The scientists have taken inspiration from the structures of the dragonfly wings.
“There is an urgent need for a better way to disinfect surfaces without causing bacterial resistance or harm to the environment. This will help us to prevent the transmission of infectious diseases from contact with surfaces,” said professor Jackie Y. Ying, executive director at the Singapore-based Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and research (A*STAR).
80% of common infections are spread by hands. Disinfecting commonly touched surfaces helps to reduce the spread of harmful germs, but would require manual and repeated disinfection because germs grow rapidly.
Current disinfectants may also contain chemicals like triclosan, which are not recognised as safe and effective, and may lead to bacterial resistance and environmental contamination if used extensively.
To tackle this problem, a team of researchers led by IBN group leader Dr Yugen Zhang created a novel nano coating that can spontaneously kill bacteria upon contact. Inspired by studies on dragonflies and cicadas, the IBN scientists grew nanopilllars of zinc oxide, a compound known for its anti-bacterial and non-toxic properties.
Zinc oxide nanopillars that looked like a bed of nails can kill a broad range of germs when used as a coating on frequently-touched surfaces. Photo IBN
Studies have shown that the wings of dragonflies and cicadas prevent bacterial growth due to their natural structure. The surfaces of their wings are covered in nanopillars making them look like a bed of nails. When bacteria come into contact with these surfaces, their cell membranes get ripped apart immediately and they are killed.
Inspired by such structure, the researchers have invented an anti-bacterial nano coating for disinfecting frequently touched surfaces such as door handles, tables and lift buttons.
This technology will prove particularly useful in creating bacteria-free surfaces in places like hospitals and clinics, where sterilisation is important to help control the spread of infections.
The zinc oxide nanopillars can kill a broad range of germs like E. coli and S. aureus that are commonly transmitted from surface contact.
Tests on ceramic, glass, titanium and zinc surfaces showed that the coating effectively killed up to 99.9% of germs found on the surfaces. As the bacteria are killed mechanically rather than chemically, the use of the nano coating would not contribute to environmental pollution. Also, the bacteria will not be able to develop resistance as they are completely destroyed when their cell walls are pierced by the nanopillars upon contact.
E. coli bacteria destroyed by the anti-bacterial coating made from zinc oxide nanopillars. Photo IBN
Further studies revealed that the nano coating demonstrated the best bacteria killing power when it is applied on zinc surfaces, compared with other surfaces. This is because the zinc oxide nanopillars catalysed the release of superoxides (or reactive oxygen species), which could even kill nearby free floating bacteria that were not in direct contact with the surface. This super bacteria killing power from the combination of nanopillars and zinc broadens the scope of applications of the coating beyond hard surfaces.
Subsequently, the researchers studied the effect of placing a piece of zinc that had been coated with zinc oxide nanopillars into water containing E. coli. All the bacteria were killed, suggesting that this material could potentially be used for water purification.
Dr Zhang commented: “Our nano coating is designed to disinfect surfaces in a novel yet practical way. This study demonstrated that our coating can effectively kill germs on different types of surfaces, and also in water. We were also able to achieve super bacteria killing power when the coating was used on zinc surfaces because of its dual mechanism of action. We hope to use this technology to create bacteria-free surfaces in a safe, inexpensive and effective manner, especially in places where germs tend to accumulate.”
IBN has recently received a grant from the National Research Foundation, Prime Minister’s Office, Singapore, under its Competitive Research Programme to further develop this coating technology in collaboration with Tan Tock Seng Hospital for commercial application over the next 5 years.
Their new research was recently published in the journal Small.