Researchers from Temple University in Pennsylvania have shown that a human monoclonal antibody with pan-amyloid-binding activity (mAb 3H3) can disrupt biofilms formed by Salmonella enterica serovar Typhimurium in vivo and in vitro.
Since curli amyloid fibres are key to the formation of Enterobacteriaceae biofilms, interrupting the function of these causes fatal problems for the bacteria.
"The ability of 3H3 to inhibit polymerisation of curli monomers suggests that some of its anti-biofilm activity may involve inhibiting the development of full-length curli fibrils," the paper stated.
The study also explained that 3H3 not only prevented the formation of biofilms but also loosened the topography of existing biofilms.
To view the entire peer-review study in Nature Communications, click here.
