Will allow bioprocess scientists to implement DoE into their workflow for simpler process optimisation
ambr 15 system, now with integrated DoE software, a leading micro bioreactor system for cell line development and early process optimisation
The 2015 version of Sartorius Stedim Biotech's (SSB) ambr systems (ambr 15 and ambr 250) will be supplied with integrated BioPAT MODDE Software for Design of Experiments (DoE), powered by Umetrics. The company says this will allow bioprocess scientists to implement DoE into their workflow for simpler process optimisation and scale-up to larger single-use BIOSTAT pilot and manufacturing scale bioreactors, making bioprocess development faster and more cost-effective.
The integrated DoE software will enable scientists to establish a design space where relevant bioprocessing conditions are varied simultaneously.
Users can rapidly configure DoE experiments through work packets that are exported from the software to the ambr system; configuring each micro bioreactor with its own DoE defined bioprocessing parameters.
The data generated from ambr, including offline analytics, is analysed within the software to identify critical process parameters, optimise bioprocessing conditions and define a robust design space for implementation in larger single-use BIOSTAT pilot and manufacturing scale bioreactors.
ambr 250 system, now with integrated DoE software, the high throughput scale-down model for process development
This extended DoE functionality is also available to existing ambr users who can assess the utility of the BioPAT MODDE software through a free 60-day trial, with the option of purchasing the full version if they want to continue to run DoE programmes.
Dr Barney Zoro, ambr15 Product Manager at Sartorius Stedim Biotech, said: 'To facilitate greater implementation of DoE across the industry we have combined the power of ambr with the BioPAT MODDE software. These synergistic technologies are ideally suited to media optimisation and process parameter screening applications. Additionally, the software can be used for Monte Carlo Simulations as part of a Quality by Design (QbD) programme to identify the desired operating region for manufacturing scale processes, to make scale-up quicker and simpler.'