Sartorius and Repligen collaborate on perfusion-enabled bioreactors

Joint technology to control cell growth, fluid management and cell retention would simplify development and cGMP manufacture of biological drugs

Perfusion cell culture application: Repligenís XCell ATF cell retention control technology will be integrated into SSBís BIOSTAT STR large-scale single-use bioreactors

Sartorius Stedim Biotech (SSB) and Repligen Corporation have partnered to integrate Repligenís XCell ATF cell retention control technology into SSBís BIOSTAT STR large-scale single-use bioreactors to create novel perfusion-enabled bioreactors.

As a result of this collaboration, end users will stand to benefit from a single control system for 50Ė2000 litre bioreactors used in perfusion cell culture applications.

This single interface is designed to control cell growth, fluid management and cell retention in continuous and intensified bioprocessing and ultimately, simplify the development and cGMP manufacture of biological drugs.

Christine Gebski, VP of Product Management at Repligen, commented: ďWe are excited to partner with SSB, a global innovator in bioreactor technology.

"The integration of our market-leading XCell ATF control technology with SSBís high-performance bioreactors offers a simplified perfusion-enabled bioreactor solution for end users to develop cell culture processes more quickly and implement perfusion more efficiently.Ē

Through the partnership, SSB and Repligen will further collaborate to equip SSBís recently launched ambr 250ht perfusion single-use mini bioreactor system with Repligenís KrosFlo hollow fibre filter technology.

The bioreactor system will be sold by SSB as a complete single-use assembly. This optimal design conserves the hollow fibre filter technology across scales, enabling customers to fast track development and scale up their cell culture perfusion processes.

ďSartorius Stedim Biotech has continuously expanded its integrated upstream portfolio for the past years with a focus on robust and scalable, automated single-use solutions, optimized for high-cell-density applications. The collaboration with Repligen will result in easy-to-implement, high-performance and perfusion-ready bioreactors ranging from process development to commercial manufacturing scale,Ē commented Stefan Schlack, Head of Marketing at SSB.

SSB is an international supplier for the biopharmaceutical industry and Repligen is a global life sciences company focused on bioprocessing technologies.

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