With Mobius FlexReady Solutions, says Millipore, users can install equipment, configure applications and validate their processes quickly and easily, significantly shortening development and manufacturing time. The process-ready hardware systems are ergonomically designed for faster set-up, maximum adaptability to changing process needs and minimised operator error risk. Modular, interlocking filter carts that can be used with other Mobius FlexReady systems with easy to interchange filter stands allow the assemblies to be moved to any point on the production line where they are needed.
The Mobius FlexReady Solution for Clarification consists of single-use Flexware assemblies, innovative separation devices, and process-ready hardware systems. Available in two sizes – a two-cart design for lab scale (CL-1) and a three-cart design for pilot scale (CL-2) Pod devices – it features the Millistak+ Pod clarification filter, which is optimised for primary and secondary clarification.
The Mobius FlexReady Solution for Virus Filtration offers optimal operational flexibility, from process development to clinical production to small-scale commercial manufacturing. Also available in two sizes with filter areas of 0.017m2 and 0.22m2 respectively, it combines the next generation Viresolve Pro Modus devices with a Viresolve Prefilter, for high levels of retention and productivity. Typical processing capacities are 500 – 1,000 L/m2, with a typical processing time of 2 – 4 hours and batch sizes of 1–8 litres and 20–200 litres.
The Mobius FlexReady Solution for Tangential Flow Filtration features Millipore’s Pellicon cassettes, which are suitable for purification or concentration/diafiltration of monoclonal antibodies, vaccines and therapeutic proteins. It comes in two sizes for optimum scalability: 10L retentate recycle tank and Pellicon holder with 0.1 to 0.5 m2 cassettes; and 50L retentate recycle tank and Pellicon cassette holder with 0.5 to 2.5 m2 cassettes. It features efficient mixing with novel tank that incorporates a levitating magnetic impeller.
Mobius FlexReady Solution for Buffer and Media Preparation features Millipore Express high-performance, sterilising-grade filters, while the hardware systems integrate easily with Mobius MIX100, MIX200 and MIX500 single-use mixing systems qualified for typical cell culture media and buffer applications. It is designed for preparation of media or buffer in 100L, 200L, 500L batch sizes for optimum scalability.
‘Mobius FlexReady Solutions now set a whole new standard for operational flexibility,’ said Paul Chapman, Millipore Corporation’s vice president, Downstream Processing. ‘Customers want more flexibility with varied batch sizes, faster processing times and more efficiency in their unit operations. We developed the Mobius FlexReady Solutions based on these requirements and with a large degree of engineering and device integration analysis.’
Contact www.millipore.com