Water quality validated on-line

Published: 20-Sep-2006


GE Analytical Instruments, a division of GE Water & Process Technologies, is offering a new Sievers 500 RL on-line TOC analyser that provides continuous quality assurance for on-line pharmaceutical water release and cleaning validation.

“Before designing the Sievers 500 RL, we investigated why so few companies were using TOC for real-time water release,” said Stephen Poirier, vice-president of business development for GE Analytical Instruments. “We learned that reliability was their main concern. Our customers told us they needed a much higher level of reliability and automation to achieve their real-time release quality initiatives. By incorporating the widely-validated Sievers laboratory TOC technology with new automation features in the 500 RL, we have essentially brought laboratory confidence to the production floor.”

The reagentless, automated analyser incorporates features such as the Super iOS (integrated on-line sampling system) that automate high-risk and frequently performed activities, significantly reducing labour costs and eliminating the delays associated with laboratory analyses.

The new Sievers Super iOS standards introduction device fully automates the delivery of multiple standards. It has four vial ports that accept pre-built vial set cartridges, and therefore automates all system protocols, including system suitability, verification, and calibration.


The new analyser has many productivity and ease-of-use features, including 12-month calibration stability, a colour touch-screen display, USB port, and minimal maintenance (a few hours per year). With a wide operating range of 0.03 ppb to 2,500 ppb, the 500 RL also measures USP <645> conductivity.

Optional Sievers DataGuard 500 software facilitates 21 CFR Part 11 compliance, including system security assurance, electronic signature capability, and the creation of an automatic, independently generated audit trail.

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