Wet chemistry isolation

Hosokawa Micron's Containment Division has recently developed wet chemistry isolator technology in conjunction with a custom synthesis company. Designed to enclose a fully assembled and operating, small scale bulk active pharmaceutical manufacturing plant including reaction vessel, crystallisation equipment and filtration vessels, the isolators give easy but contained operator access for product input, product removal, operational adjustment and maintenance. The new Stott isolator has been developed in response to health and safety concerns for personnel working directly with the liquid forms of increasingly concentrated active, toxic ingredients used in pharmaceutical production. The single chamber isolator offers two modes of operation, an isolator mode providing Operator Exposure Levels of <1mcg/m3 8hr TWA and an airflow mode to provide, by the use of inflow air velocity through the doors, an Operator Exposure Level of <200mcg/m3 8hr TWA. The isolator is also designed to ensure any solvent vapour concentration remains below the lower explosion limit.

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